TP53 mutation and immunohistochemical p53 expression characteristics in diffuse large B–cell lymphoma

Abstract excerpt

Diffuse large B-cell lymphoma (DLBCL) with TP53 mutations has specific clinicopathological features and is usually associated with a poor prognosis. TP53 gene mutations typically lead to aberrant expression patterns of the p53 protein. We studied 123 DLBCL patients at Henan Cancer Hospital, 35.8% (44/123) had TP53 mutations. Analysis of mutation sites in 44 cases of DLBCL patients revealed that the mutations...

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