Real-world routine diagnostic molecular analysis for TP53 mutational status is recommended over p53 immunohistochemistry in B-cell lymphomas.

doi:10.1007/s00428-023-03676-6

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Real-world routine diagnostic molecular analysis for TP53 mutational status is recommended over p53 immunohistochemistry in B-cell lymphomas.

Virchows Archiv : an international journal of pathology - 1 Oct 2024

de Haan Lorraine M, de Groen Ruben A L, de Groot Fleur A, Noordenbos Troy, van Wezel Tom, van Eijk Ronald, Ruano Dina, Diepstra Arjan, Koens Lianne, Nicolae-Cristea Alina, Hartog Wietske C E den, Terpstra Valeska, Ahsmann Els, Dekker Tim J A, Sijs-Szabo Aniko, Veelken Hendrik, Cleven Arjen H G, Jansen Patty M, Vermaat Joost S P

Abstract excerpt

Previous studies in patients with mature B-cell lymphomas (MBCL) have shown that pathogenic TP53 aberrations are associated with inferior chemotherapeutic efficacy and survival outcomes. In solid malignancies, p53 immunohistochemistry is commonly used as a surrogate marker to assess TP53 mutations, but this correlation is not yet well-established in lymphomas. This study evaluated the accuracy of p53...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomarkers, Tumor

Share to DNA Mutational Analysis

Share to High-Throughput Nucleotide Sequencing

Share to Immunohistochemistry

Share to Lymphoma, B-Cell

Share to Reproducibility of Results

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 37851120
DOI: 10.1007/s00428-023-03676-6
PMCID: PMC11522076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Real-world routine diagnostic molecular analysis for TP53 mutational status is recommended over p53 immunohistochemistry in B-cell lymphomas.PMID 37851120Read ↗

Accurate interpretation of p53 immunohistochemical patterns is a surrogate biomarker for TP53 alterations in large B-cell lymphoma.Semantic proximity Read ↗

TP53 mutations predict for poor outcomes in patients with newly diagnosed aggressive B-cell lymphomas in the current era.Semantic proximity Read ↗

TP53 mutation predict poor prognosis in diffuse large B-cell lymphoma: a single-center study.Semantic proximity Read ↗

Real-world Comparison of P53 Immunohistochemistry and TP53 Mutation Analysis Using Next-generation Sequencing.Semantic proximity Read ↗

Optimized interpretation of p53 immunohistochemistry for prediction of TP53 mutations and patient survival in DLBCL.Semantic proximity Read ↗

P53 immunohistochemistry is an ideal surrogate marker for TP53 mutation and a predictor of early metastasis in breast cancer: Real-world analysisSemantic proximity Read ↗

Impact of TP53 mutations on survival outcomes in the CAR-T era of large B-cell lymphoma.Semantic proximity Read ↗

p53 immunohistochemistry must be confirmed by TP53 next generation sequencing for accurate risk stratification of patients with mantle cell lymphoma.Semantic proximity Read ↗

Predictive and prognostic molecular biomarkers in lymphomas.Semantic proximity Read ↗

TP53 mutation and survival in aggressive B cell lymphoma.Semantic proximity Read ↗

Integrative Molecular Analysis Reveals Determinants of Clinical Outcomes in TP53-Mutated Diffuse Large B-Cell Lymphoma.Semantic proximity Read ↗

p53 immunostaining pattern is a useful surrogate marker for TP53 gene mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.