Article
Discriminating functional and non-functional p53 in human tumours by p53 and MDM2 immunohistochemistry.
The Journal of pathology - 1 Nov 2005
Nenutil R, Smardova J, Pavlova S, Hanzelkova Z, Muller P, Fabian P, Hrstka R, Janotova P, Radina M, Lane D P, Coates P J, Vojtesek B
Abstract excerpt
Mutation and/or loss of the TP53 tumour suppressor gene is the single most common genetic abnormality in human cancer. The majority of TP53 mutations lead to stabilization of the protein, so that immunohistochemical staining for p53 can suggest mutation status in many cases. However, various false-positive and false-negative situations mean that simple immunostaining for p53 is not informative in a substantial...
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