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Article

Aberrant Rho GTPases signaling and cognitive dysfunction: in vivo evidence for a compelling molecular relationship.

Neuroscience and biobehavioral reviews - 1 Oct 2014

De Filippis Bianca, Romano Emilia, Laviola Giovanni

Abstract excerpt

Rho GTPases are key intracellular signaling molecules that coordinate dynamic changes in the actin cytoskeleton, thereby stimulating a variety of processes, including morphogenesis, migration, neuronal development, cell division and adhesion. Deviations from normal Rho GTPases activation state have been proposed to disrupt cognition and synaptic plasticity. This review focuses on the functional consequences of...

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PMID: 24971827
DOI: 10.1016/j.neubiorev.2014.06.007

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