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Article

Effects of distinct n-6 to n-3 polyunsaturated fatty acid ratios on insulin resistant and AD-like phenotypes in high-fat diets-fed APP/PS1 mice.

Food research international (Ottawa, Ont.) - 1 Dec 2022

Ma Xiaojun, Guo Yujie, Xu Jingjing, Wang Xixiang, Dong Shengqi, Gao Yanyan, Van Halm-Lutterodt Nicholas, Yuan Linhong

Abstract excerpt

Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) are prevalent diseases with similar pathophysiological characteristics and genetic predispositions. Polyunsaturated fatty acids (PUFAs) are essential in maintaining normal brain function. However, little is known about the effect of dietary n-6/n-3 PUFA ratio on AD-like pathology, particularly in high-fat diet (HFD)-fed AD model mice. In the present...

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Identifiers

PMID: 36461380
DOI: 10.1016/j.foodres.2022.112207

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