Article

Exenatide reverts the high-fat-diet-induced impairment of BDNF signaling and inflammatory response in an animal model of Alzheimer’s disease

2018-12-04

Abstract excerpt

<h4>Background</h4> preclinical, clinical, and epidemiological evidence support the notion that Alzheimer’s disease(AD) is a multifactorial condition in which, along with β-amyloid (Aβ) and tau-related pathology, the synergistic activity of genetic, environmental, vascular, metabolic, and inflammatory factors promote the onset and progression of the disease. Epidemiological evidence indicate that glucose intolera...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5e753ef1-a181-5521-a82e-f59e6e23d492
DOI: 10.1101/487629

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exenatide reverts the high-fat-diet-induced impairment of BDNF signaling and inflammatory response in an animal model of Alzheimer’s diseaseDOI 10.1101/487629Read

Spotlight on the Pathophysiological Trajectories Linked to Alzheimer’s Disease (AD): Blood-Brain Barrier (BBB); Neuroinflammation; APOE4 Allele and AD- Insulin Resistance (IR) Pathogenic LinkSemantic proximity Read

Young APPKI <sup>NL-G-F/NL-G-F</sup> mice display high-fat diet-induced metabolic disturbances and specific disorders associated with brain energy homeostasisSemantic proximity Read

Navigation Between Alzheimer’s Disease (AD) and Its Various Pathophysiological Trajectories: The Pathogenic Link to Neuroimmunology—Genetics and NeuroinflammationSemantic proximity Read

Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegenerationSemantic proximity Read

Experimental Induction of Type 2 Diabetes in Aging-Accelerated Mice Triggered Alzheimer-Like Pathology and Memory DeficitsSemantic proximity Read

Exendin-4 Improves Long-Term Potentiation and Neuronal Dendritic Growth in High-Fat Diet Mice and Neurons Under Metabolic Imbalance ConditionsSemantic proximity Read

Effects of Distinct n-6 to n-3 Polyunsaturated Fatty Acid Rations on Insulin Resistant and AD-like Phenotypes in High-Fat Diets-Fed APP/PS1 Transgenic MiceSemantic proximity Read

Effects of distinct n-6 to n-3 polyunsaturated fatty acid ratios on insulin resistant and AD-like phenotypes in high-fat diets-fed APP/PS1 mice.Semantic proximity Read

Ketogenic interventions restore cognition and modulate peripheral metabolic dysfunctions in Alzheimer’s disease mouse modelsSemantic proximity Read

Understanding the link between insulin resistance and Alzheimer’s disease: Insights from animal modelsSemantic proximity Read

Intermittent fasting mitigates cognitive deficits in Alzheimer’s disease via the gut-brain axisSemantic proximity Read

A Potential Role for the Ketogenic Diet in Alzheimer’s Disease Treatment: Exploring Pre-clinical and Clinical EvidencesSemantic proximity Read