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Article

Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice.

Biochimica et biophysica acta. Molecular basis of disease - 1 Jan 2018

Nam Kyong Nyon, Wolfe Cody M, Fitz Nicholas F, Letronne Florent, Castranio Emilie L, Mounier Anais, Schug Jonathan, Lefterov Iliya, Koldamova Radosveta

Abstract excerpt

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that is influenced by genetic and environmental risk factors, such as inheritance of ε4 allele of APOE (APOE4), sex and diet. Here, we examined the effect of high fat diet (HFD) on amyloid pathology and expression profile in brains of AD model mice expressing human APOE isoforms (APP/E3 and APP/E4 mice). APP/E3 and APP/E4 mice were fed HFD or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29038051
DOI: 10.1016/j.bbadis.2017.10.018
PMCID: PMC5714325

Genes

APP
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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