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Article

High-fat diet protects the blood-brain barrier in an Alzheimer's disease mouse model.

Aging cell - 1 Oct 2018

Elhaik Goldman Shirin, Goez David, Last David, Naor Sharone, Liraz Zaltsman Sigal, Sharvit-Ginon Inbal, Atrakchi-Baranes Dana, Shemesh Chen, Twitto-Greenberg Rachel, Tsach Shoval, Lotan Roni, Leikin-Frenkel Alicia, Shish Aviv, Mardor Yael, Schnaider Beeri Michal, Cooper Itzik

Abstract excerpt

Type 2 diabetes (T2D) is associated with increased risk of Alzheimer's disease (AD). There is evidence for impaired blood-brain barrier (BBB) in both diseases, but its role in the interplay between them is not clear. Here, we investigated the effects of high-fat diet (HFD), a model for T2D, on the Tg2576 mouse model of AD, in regard to BBB function. We showed that HFD mice had higher weight, more insulin...

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Identifiers

PMID: 30079520
DOI: 10.1111/acel.12818
PMCID: PMC6156545

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