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Article

Changes of Mutations and Copy-Number and Enhanced Cell Migration during Breast Tumorigenesis.

Advanced biology - 1 Feb 2023

Lee Seung Hyuk T, Kim Joon Yup, Kim Peter, Dong Zhipeng, Su Chia-Yi, Ahn Eun Hyun

Abstract excerpt

Although cancer stem cells (CSCs) play a major role in tumorigenesis and metastasis, the role of genetic alterations in invasiveness of CSCs is still unclear. Tumor microenvironment signals, such as extracellular matrix (ECM) composition, significantly influence cell behaviors. Unfortunately, these signals are often lost in in vitro cell culture. This study determines putative CSC populations, examines genetic...

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Identifiers

PMID: 36449747
DOI: 10.1002/adbi.202200072
PMCID: PMC10836759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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