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Serial single-cell RNA sequencing unveils drug resistance and metastatic traits in stage IV breast cancer

3 Oct 2024

Abstract excerpt

Metastasis is a complex process that remains poorly understood at the molecular levels. We profiled single-cell transcriptomic, genomic, and epigenomic changes associated with cancer cell progression, chemotherapy resistance, and metastasis from a Stage IV breast cancer patient. Pretreatment- and posttreatment-specimens from the primary tumor and distant metastases were collected for single-cell RNA sequencing...

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PMID: 39363009
DOI: 10.1038/s41698-024-00723-6

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