Article
Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient.
Breast cancer research and treatment - 1 Jul 2018
Johnson Julie, Bessette Darrell C, Saunus Jodi M, Smart Chanel E, Song Sarah, Johnston Rebecca L, Cocciardi Sibylle, Rozali Esdy N, Johnstone Cameron N, Vargas Ana Christina, Kazakoff Stephen H, BioBank Victorian Cancer, Khanna Kum Kum, Lakhani Sunil R, Chenevix-Trench Georgia, Simpson Peter T, Nones Katia, Waddell Nicola, Al-Ejeh Fares
Abstract excerpt
PURPOSE: We aimed to generate and characterize a novel cell line from a breast cancer bone metastasis to better study the progression of the disease. METHODS: The cell line, P7731, was derived from a metastatic bone lesion of a breast cancer patient and assessed for marker expression. P7731 was analyzed for DNA copy number variation, somatic mutations, and gene expression and was compared with the primary tumor....
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