Article
A genome-wide association study identifies a novel association between SDC3 and apparent treatment-resistant hypertension.
BMC medicine - 30 Nov 2022
Xiao Xiao, Li Rui, Wu Cunjin, Yan Yupeng, Yuan Mengmeng, Cui Bing, Zhang Yu, Zhang Channa, Zhang Xiaoxia, Zhang Weili, Hui Rutai, Wang Yibo
Abstract excerpt
BACKGROUND: Compared with patients who require fewer antihypertensive agents, those with apparent treatment-resistant hypertension (aTRH) are at increased risk for cardiovascular and all-cause mortality, independent of blood pressure control. However, the etiopathogenesis of aTRH is still poorly elucidated. METHODS: We performed a genome-wide association study (GWAS) in first cohort including 586 aTRHs and 871...
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