Article
Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group.
American journal of hypertension - 15 Nov 2019
Irvin Marguerite R, Sitlani Colleen M, Floyd James S, Psaty Bruce M, Bis Joshua C, Wiggins Kerri L, Whitsel Eric A, Sturmer Til, Stewart James, Raffield Laura, Sun Fangui, Liu Ching-Ti, Xu Hanfei, Cupples Adrienne L, Tanner Rikki M, Rossing Peter, Smith Albert, Zilhão Nuno R, Launer Lenore J, Noordam Raymond, Rotter Jerome I, Yao Jie, Li Xiaohui, Guo Xiuqing, Limdi Nita, Sundaresan Aishwarya, Lange Leslie, Correa Adolfo, Stott David J, Ford Ian, Jukema J Wouter, Gudnason Vilmundur, Mook-Kanamori Dennis O, Trompet Stella, Palmas Walter, Warren Helen R, Hellwege Jacklyn N, Giri Ayush, O'donnell Christopher, Hung Adriana M, Edwards Todd L, Ahluwalia Tarunveer S, Arnett Donna K, Avery Christy L
Abstract excerpt
BACKGROUND: Only a handful of genetic discovery efforts in apparent treatment-resistant hypertension (aTRH) have been described. METHODS: We conducted a case-control genome-wide association study of aTRH among persons treated for hypertension, using data from 10 cohorts of European ancestry (EA) and 5 cohorts of African ancestry (AA). Cases were treated with 3 different antihypertensive medication classes and had...
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