Article
A Closer Look at Estrogen Receptor Mutations in Breast Cancer and Their Implications for Estrogen and Antiestrogen Responses.
International journal of molecular sciences - 13 Jan 2021
Clusan Léa, Le Goff Pascale, Flouriot Gilles, Pakdel Farzad
Abstract excerpt
Breast cancer (BC) is the most common cancer among women worldwide. More than 70% of BC cases express estrogen receptor alpha (ERα), a central transcription factor that stimulates the proliferation of breast cancer cells, usually in the presence of estrogen. While most cases of ER-positive BC initially respond to antiestrogen therapies, a high percentage of cases develop resistance to treatment over time. The...
Topics
- Animals
- Antineoplastic Agents, Hormonal
- Biomarkers, Tumor
- Breast Neoplasms
- Disease Management
- Disease Susceptibility
- Estrogen Antagonists
- Estrogen Receptor alpha
- Estrogens
- Female
- Humans
- Molecular Targeted Therapy
- Mutation
- Mutation, Missense