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The role of tyrosine hydroxylase–dopamine pathway in Parkinson’s disease pathogenesis

21 Nov 2022

Abstract excerpt

BACKGROUND: Parkinson's disease (PD) is characterized by selective and progressive dopamine (DA) neuron loss in the substantia nigra and other brain regions, with the presence of Lewy body formation. Most PD cases are sporadic, whereas monogenic forms of PD have been linked to multiple genes, including Leucine kinase repeat 2 (LRRK2) and PTEN-induced kinase 1 (PINK1), two protein kinase genes involved in multiple...

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PMID: 36409355
DOI: 10.1007/s00018-022-04574-x

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