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Article

MicroRNA-599 regulates the development of Parkinson's disease through mediating LRRK2 expression.

1 Jan 2019

Abstract excerpt

OBJECTIVE: This study investigates whether microRNA-599 can inhibit the progression of Parkinson's disease (PD) by regulating the LRRK2 expression. We aim to search for a new therapeutic target for PD. MATERIALS AND METHODS: A mouse model of PD was first established. A relative amount of TH+ neurons in the mouse brain was quantified by immunohistochemistry. The expression levels of microRNA-599 and LRRK2 in mouse...

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PMID: 30720180
DOI: 10.26355/eurrev_201901_16886

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