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Article

Evidence of emerging BBB changes in mid‐age apolipoprotein E epsilon‐4 carriers

21 Nov 2022

Abstract excerpt

INTRODUCTION: Studies have recognized that the loss of the blood-brain barrier (BBB) integrity is a major structural biomarker where neurodegenerative disease potentially begins. Using a combination of high-quality neuroimaging techniques, we investigated potential subtle differences in BBB permeability in mid-age healthy people, comparing carriers of the apolipoprotein E epsilon-4 (APOEε4) genotype, the biggest...

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PMID: 36408825
DOI: 10.1002/brb3.2806

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