Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apolipoprotein E affects both myelin breakdown and cognition: implications for age-related trajectories of decline into dementia.

Biological psychiatry - 15 Dec 2007

Bartzokis George, Lu Po H, Geschwind Daniel H, Tingus Kathleen, Huang Danny, Mendez Mario F, Edwards Nancy, Mintz Jim

Abstract excerpt

BACKGROUND: Age-related myelin breakdown is most evident in later-myelinating white matter (LMwm) brain regions. This process might degrade cognitive processing speed (CPS) underlying age-related cognitive decline and the predominance of age as a risk factor for Alzheimer's disease (AD). Apolipoprotein E (ApoE) 4 allele is the second most important AD risk factor. We tested the hypothesis that ApoE4 accelerates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Apolipoproteins E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chi-Square Distribution

Share to Cognition Disorders

Share to Dementia

Share to Magnetic Resonance Imaging

Share to Myelin Sheath

Share to Neuropsychological Tests

Source

Identifiers

PMID: 17659264
DOI: 10.1016/j.biopsych.2007.03.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apolipoprotein E affects both myelin breakdown and cognition: implications for age-related trajectories of decline into dementia.PMID 17659264Read ↗

Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementia.Semantic proximity Read ↗

Differential associations between apolipoprotein E alleles and cerebral myelin content in normative aging.Semantic proximity Read ↗

Interactive effect of age and APOE-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjectsSemantic proximity Read ↗

APOE ε4 allele accelerates age-related multi-cognitive decline and white matter damage in non-demented elderly.Semantic proximity Read ↗

Brain myelin water fraction is associated with APOE4 allele status in patients with cognitive impairment.Semantic proximity Read ↗

Apolipoprotein E-e4, processing speed, and white matter volume in a genetically enriched sample of midlife adults.Semantic proximity Read ↗

Genetic risk of dementia modifies the impact of obesity on limbic white matter and spatial navigation behavior in cognitively healthy adultsSemantic proximity Read ↗

Higher rates of decline for women and apolipoprotein E epsilon4 carriers.Semantic proximity Read ↗

Microstructural White Matter Properties Mediate the Association between APOE and Perceptual Speed in Very Old Persons without Dementia.Semantic proximity Read ↗

Interaction of APOE e4 and poor glycemic control predicts white matter hyperintensity growth from 73 to 76.Semantic proximity Read ↗

Effects of APOE on brain white matter microstructure in healthy adults.Semantic proximity Read ↗

The Elusive Nature of APOE ε4 in Mid-adulthood: Understanding the Cognitive ProfileSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.