Article
Genome-wide admixture and association analysis identifies African ancestry-specific risk loci of eosinophilic esophagitis in African Americans.
The Journal of allergy and clinical immunology - 1 May 2023
Gautam Yadu, Caldwell Julie, Kottyan Leah, Chehade Mirna, Dellon Evan S, Rothenberg Marc E, Mersha Tesfaye B
Abstract excerpt
BACKGROUND: Eosinophilic esophagitis (EoE), a chronic allergic inflammatory disease, is linked to multiple genetic risk factors, but studies have focused on populations of European ancestry. Few studies have assessed Black or African American (AA) populations for loci involved in EoE susceptibility. OBJECTIVE: We performed admixture mapping (AM) and genome-wide association study (GWAS) of EoE using participants...
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