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Article

Barrett's esophagus-associated genetic loci in African Americans: a case-control study using the All of Us Research Program.

European journal of gastroenterology & hepatology - 1 Jun 2026

Rao Ashwin, Byun Jinyoung, Thrift Aaron P, El-Serag Hashem B

Abstract excerpt

BACKGROUND AND AIMS: Barrett's esophagus is the only known precursor lesion to esophageal adenocarcinoma (EAC). Barrett's esophagus and EAC are less common in African Americans than in non-Hispanic Whites. Studies in European populations have identified Barrett's esophagus-associated risk loci; however, none have examined loci in African Americans cohorts. We conducted a case-control targeted replication study to...

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Identifiers

PMID: 41524576
DOI: 10.1097/MEG.0000000000003131
PMCID: PMC13127735

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