Article
Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.
Nature genetics - 1 Aug 2014
Kottyan Leah C, Davis Benjamin P, Sherrill Joseph D, Liu Kan, Rochman Mark, Kaufman Kenneth, Weirauch Matthew T, Vaughn Samuel, Lazaro Sara, Rupert Andrew M, Kohram Mojtaba, Stucke Emily M, Kemme Katherine A, Magnusen Albert, He Hua, Dexheimer Phillip, Chehade Mirna, Wood Robert A, Pesek Robbie D, Vickery Brian P, Fleischer David M, Lindbad Robert, Sampson Hugh A, Mukkada Vincent A, Putnam Phil E, Abonia J Pablo, Martin Lisa J, Harley John B, Rothenberg Marc E
Abstract excerpt
Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder associated with allergic hypersensitivity to food. We interrogated >1.5 million genetic variants in EoE cases of European ancestry and subsequently in a multi-site cohort with local and out-of-study control subjects. In addition to...
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