Article
Genomic regions associated with susceptibility to Barrett's esophagus and esophageal adenocarcinoma in African Americans: The cross BETRNet admixture study.
PloS one - 1 Jan 2017
Sun Xiangqing, Chandar Apoorva K, Canto Marcia I, Thota Prashanthi N, Brock Malcom, Shaheen Nicholas J, Beer David G, Wang Jean S, Falk Gary W, Iyer Prasad G, Abrams Julian A, Venkat-Ramani Medha, Veigl Martina, Miron Alexander, Willis Joseph, Patil Deepa T, Nalbantoglu Ilke, Guda Kishore, Markowitz Sanford D, Zhu Xiaofeng, Elston Robert, Chak Amitabh
Abstract excerpt
BACKGROUND: Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) are far more prevalent in European Americans than in African Americans. Hypothesizing that this racial disparity in prevalence might represent a genetic susceptibility, we used an admixture mapping approach to interrogate disease association with genomic differences between European and African ancestry. METHODS: Formalin fixed paraffin...
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