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Article

Arrhythmogenic calmodulin variants D131E and Q135P disrupt interaction with the L-type voltage-gated Ca2+ channel (Cav1.2) and reduce Ca2+-dependent inactivation.

Acta physiologica (Oxford, England) - 1 Feb 2025

Gupta Nitika, Richards Ella M B, Morris Vanessa S, Morris Rachael, Wadmore Kirsty, Held Marie, McCormick Liam, Prakash Ohm, Dart Caroline, Helassa Nordine

Abstract excerpt

AIM: Long QT syndrome (LQTS) and catecholaminergic polymorphism ventricular tachycardia (CPVT) are inherited cardiac disorders often caused by mutations in ion channels. These arrhythmia syndromes have recently been associated with calmodulin (CaM) variants. Here, we investigate the impact of the arrhythmogenic variants D131E and Q135P on CaM's structure-function relationship. Our study focuses on the L-type...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39825574
DOI: 10.1111/apha.14276
PMCID: PMC11742489

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