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Article

Properties of Calmodulin Binding to NaV1.2 IQ Motif and Its Autism-Associated Mutation R1902C.

Neurochemical research - 1 Mar 2021

Jia Wanying, Liu Junyan, Yu Zhiyi, Zhang Xiaohong, Xu Xiaoxue, Wang Yuting, Gao Qinghua, Feng Rui, Wan Yujun, Xu Jianjun, Minobe Etsuko, Kameyama Masaki, Wang Wuyang, Guo Feng

Abstract excerpt

Voltage-gated sodium channels (VGSCs) are fundamental to the initiation and propagation of action potentials in excitable cells. Ca2+/calmodulin (CaM) binds to VGSC type II (NaV1.2) isoleucine and glutamine (IQ) motif. An autism-associated mutation in NaV1.2 IQ motif, Arg1902Cys (R1902C), has been reported to affect the combination between CaM and the IQ motif compared to that of the wild type IQ motif. However,...

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PMID: 33394222
DOI: 10.1007/s11064-020-03189-7

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