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Article

Calmodulin mediates Ca2+ sensitivity of sodium channels.

The Journal of biological chemistry - 22 Oct 2004

Kim James, Ghosh Smita, Liu Huajun, Tateyama Michihiro, Kass Robert S, Pitt Geoffrey S

Abstract excerpt

Ca2+ has been proposed to regulate Na+ channels through the action of calmodulin (CaM) bound to an IQ motif or through direct binding to a paired EF hand motif in the Nav1 C terminus. Mutations within these sites cause cardiac arrhythmias or autism, but details about how Ca2+ confers sensitivity...

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Source

Identifiers

PMID: 15316014
DOI: 10.1074/jbc.M407286200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15316014-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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