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Article

IL-2 availability regulates the tissue specific phenotype of murine intra-hepatic Tregs.

Frontiers in immunology - 1 Jan 2022

Kurt Ada S, Strobl Karoline, Ruiz Paula, Osborn Gabriel, Chester Tonika, Dawson Lauren, Warwas Karsten M, Grey Elizabeth H, Mastoridis Sotiris, Kodela Elisavet, Safinia Niloufar, Sanchez-Fueyo Alberto, Martinez-Llordella Marc

Abstract excerpt

CD4+CD25+Foxp3+ Tregs are known to acquire tissue-specific features and exert cytoprotective and regenerative functions. The extent to which this applies to liver-resident Tregs is unknown. In this study, we aimed to explore the phenotypic and functional characteristics of adult murine liver resident Tregs during homeostasis. Additionally, we investigated their role in ameliorating liver inflammation and tissue...

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Identifiers

PMID: 36389734
DOI: 10.3389/fimmu.2022.1040031
PMCID: PMC9661520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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