Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overcoming variant mutation-related impacts on viral sequencing and detection methodologies

28 Oct 2022

Abstract excerpt

Prompt and accurate pathogen identification, by diagnostics and sequencing, is an effective tool for tracking and potentially curbing pathogen spread. Targeted detection and amplification of viral genomes depends on annealing complementary oligonucleotides to genomic DNA or cDNA. However, genomic mutations that occur during viral evolution may perturb annealing, which can result in incomplete sequence coverage of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Plant Virus Research Studies
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36388914
DOI: 10.3389/fmed.2022.989913

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overcoming variant mutation-related impacts on viral sequencing and detection methodologiesPMID 36388914Read ↗

Impact of SARS-CoV-2 Mutations on PCR Assay Sequence Alignment.Semantic proximity Read ↗

Validation of reduced S-gene target performance and failure for rapid surveillance of SARS-CoV-2 variantsSemantic proximity Read ↗

Five years of SARS CoV-2 Evolution: Implications for RT PCR Diagnostic PerformanceSemantic proximity Read ↗

Validation of Reduced S-gene Target Performance and Failure for Rapid Surveillance of SARS-CoV-2 VariantsSemantic proximity Read ↗

Sequencing during Times of Change: Evaluating SARS-CoV-2 Clinical Samples during the Transition from the Delta to Omicron Wave.Semantic proximity Read ↗

Decoding SARS-CoV-2 variant functionality: balancing innovation and ethical oversight.Semantic proximity Read ↗

Profiling RT-LAMP tolerance of sequence variation for SARS-CoV-2 RNA detectionSemantic proximity Read ↗

“Multiplex RT-PCR for SARS-CoV-2 variant surveillance in resource-limited settings: an in-house validation study in Cuba”Semantic proximity Read ↗

Evaluation of the effects of SARS-CoV-2 genetic mutations on diagnostic RT-PCR assaysSemantic proximity Read ↗

Investigation of SARS-CoV-2 Variants at Primer Binding Sites in Diagnostic Platforms and the Effect on Laboratory Diagnostic SamplesSemantic proximity Read ↗

Mutations in emerging variant of concern lineages disrupt genomic sequencing of SARS-CoV-2 clinical specimens.Semantic proximity Read ↗

Identification of mutations in SARS-CoV-2 PCR primer regions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.