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Article

Mutations in emerging variant of concern lineages disrupt genomic sequencing of SARS-CoV-2 clinical specimens.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Jan 2022

Kuchinski Kevin S, Nguyen Jason, Lee Tracy D, Hickman Rebecca, Jassem Agatha N, Hoang Linda M N, Prystajecky Natalie A, Tyson John R

Abstract excerpt

Mutations in emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages can interfere with laboratory methods used to generate viral genome sequences for public health surveillance. We identified 20 mutations that are widespread in variant of concern lineages and affect widely used sequencing protocols by the ARTIC network and Freed et al. Three of these mutations disrupted sequencing of P.1...

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Identifiers

PMID: 34757201
DOI: 10.1016/j.ijid.2021.10.050
PMCID: PMC8555373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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