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Article

α-Synuclein may cross-bridge v-SNARE and acidic phospholipids to facilitate SNARE-dependent vesicle docking.

The Biochemical journal - 6 Jun 2017

Lou Xiaochu, Kim Jaewook, Hawk Brenden J, Shin Yeon-Kyun

Abstract excerpt

Misfolded α-synuclein (A-syn) is widely recognized as the primal cause of neurodegenerative diseases including Parkinson's disease and dementia with Lewy bodies. The normal cellular function of A-syn has, however, been elusive. There is evidence that A-syn plays multiple roles in the exocytotic pathway in the neuron, but the underlying molecular mechanisms are unclear. A-syn has been known to interact with...

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Share to Liposomes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to SNARE Proteins

Share to Synaptic Vesicles

Share to Synaptosomal-Associated Protein 25

Share to Synaptotagmin I

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Source

Open in PubMed Open full text

Identifiers

PMID: 28495859
DOI: 10.1042/BCJ20170200
PMCID: PMC5772654

Genes

VAMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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