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Article

Presymptomatic cognitive decline in familial frontotemporal dementia: A longitudinal study.

Neurology - 26 Jul 2016

Jiskoot Lize C, Dopper Elise G P, Heijer Tom den, Timman Reinier, van Minkelen Rick, van Swieten John C, Papma Janne M

Abstract excerpt

OBJECTIVE: In this prospective cohort study, we performed a 2-year follow-up study with neuropsychological assessment in the presymptomatic phase of familial frontotemporal dementia (FTD) due to GRN and MAPT mutations to explore the prognostic value of neuropsychological assessment in the earliest FTD disease stages. METHODS: Healthy, at-risk, first-degree relatives of patients with FTD who had a MAPT (n = 13) or...

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Identifiers

PMID: 27358337
DOI: 10.1212/WNL.0000000000002895

Genes

MAPT
GRN

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