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Article

Ancestry, ACKR1 and leucopenia in patients with systemic lupus erythematosus.

Lupus science & medicine - 1 Nov 2022

Chung Cecilia P, Karakoc Gul, Liu Ge, Gamboa Jorge L, Mosley Jonathan D, Cox Nancy J, Stein C Michael, Kawai Vivian

Abstract excerpt

OBJECTIVE: SLE is more prevalent in populations of African (AA) than European ancestry (EA) and leucopenia is common. A homozygous variant in ACKR1 (rs2814778-CC) is associated with lower white cell counts; the variant is common in AA but not EA populations. We hypothesised that in SLE: (1) leucopenia is more frequent in patients of AA than EA, and (2) the ACKR1-CC genotype accounts for the higher frequency of...

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Identifiers

PMID: 36376015
DOI: 10.1136/lupus-2022-000790
PMCID: PMC9664301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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