Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer

14 Nov 2022

Abstract excerpt

PURPOSE: Pancreatic cancer is the worst prognosis among all human cancers, and novel effective treatments are urgently needed. Signal transducer and activator of transcription 3 (STAT3) has been demonstrated as a promising target for pancreatic cancer. Meanwhile, selectively targeted STAT3 with small molecule remains been challenging. EXPERIMENTAL DESIGN: To specifically identify STAT3 inhibitors, more than 1.3...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cytokine Signaling Pathways and Interactions
Share to Hedgehog Signaling Pathway Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36374556
DOI: 10.1158/1078-0432.ccr-22-0997

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic CancerPMID 36374556Read ↗

Targeting STAT3 by a small molecule suppresses pancreatic cancer progressionSemantic proximity Read ↗

Strategies and Approaches of Targeting STAT3 for Cancer TreatmentSemantic proximity Read ↗

Small Molecule Inhibitors of STAT3 for Cancer TherapySemantic proximity Read ↗

Novel activators and small-molecule inhibitors of STAT3 in cancerSemantic proximity Read ↗

Signal transducer and activator of transcription 3 inhibitors: a patent reviewSemantic proximity Read ↗

Unraveling the complexity of STAT3 in cancer: molecular understanding and drug discoverySemantic proximity Read ↗

STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancersSemantic proximity Read ↗

A Small Molecule with Big Impact: MRTX1133 Targets the KRASG12D Mutation in Pancreatic Cancer.Semantic proximity Read ↗

Overview of the STAT‑3 signaling pathway in cancer and the development of specific inhibitors (Review)Semantic proximity Read ↗

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cellsSemantic proximity Read ↗

If You Cannot Win Them, Join Them: Understanding New Ways to Target STAT3 by Small MoleculesSemantic proximity Read ↗

Novel inhibitors of signal transducer and activator of transcription 3 signaling pathway: an update on the recent patent literatureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.