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Article

Genome-Wide Association with Uncertainty in the Genetic Similarity Matrix.

Journal of computational biology : a journal of computational molecular cell biology - 1 Feb 2023

Wang Shijia, Ge Shufei, Sobkowiak Benjamin, Wang Liangliang, Grandjean Louis, Colijn Caroline, Elliott Lloyd T

Abstract excerpt

Genome-wide association studies (GWASs) are often confounded by population stratification and structure. Linear mixed models (LMMs) are a powerful class of methods for uncovering genetic effects, while controlling for such confounding. LMMs include random effects for a genetic similarity matrix, and they assume that a true genetic similarity matrix is known. However, uncertainty about the phylogenetic structure...

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Identifiers

PMID: 36374242
DOI: 10.1089/cmb.2022.0067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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