Genome-wide association, prediction and heritability in bacteria with application toStreptococcus pneumoniae

Abstract excerpt

Abstract Whole-genome sequencing has facilitated genome-wide analyses of association, prediction and heritability in many organisms. However, such analyses in bacteria are still in their infancy, being limited by difficulties including genome plasticity and strong population structure. Here we propose a suite of methods including linear mixed models, elastic net and LD-score regression, adapted to bacterial...

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