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Article

Further improvements to linear mixed models for genome-wide association studies.

Scientific reports - 12 Nov 2014

Widmer Christian, Lippert Christoph, Weissbrod Omer, Fusi Nicolo, Kadie Carl, Davidson Robert, Listgarten Jennifer, Heckerman David

Abstract excerpt

We examine improvements to the linear mixed model (LMM) that better correct for population structure and family relatedness in genome-wide association studies (GWAS). LMMs rely on the estimation of a genetic similarity matrix (GSM), which encodes the pairwise similarity between every two individuals in a cohort. These similarities are estimated from single nucleotide polymorphisms (SNPs) or other genetic...

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Identifiers

PMID: 25387525
DOI: 10.1038/srep06874
PMCID: PMC4230738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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