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Article

Retrospective Binary-Trait Association Test Elucidates Genetic Architecture of Crohn Disease.

American journal of human genetics - 4 Feb 2016

Jiang Duo, Zhong Sheng, McPeek Mary Sara

Abstract excerpt

In genetic association testing, failure to properly control for population structure can lead to severely inflated type 1 error and power loss. Meanwhile, adjustment for relevant covariates is often desirable and sometimes necessary to protect against spurious association and to improve power. Many recent methods to account for population structure and covariates are based on linear mixed models (LMMs), which are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26833331
DOI: 10.1016/j.ajhg.2015.12.012
PMCID: PMC4746383

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