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Article

A multiple-phenotype imputation method for genetic studies.

Nature genetics - 1 Apr 2016

Dahl Andrew, Iotchkova Valentina, Baud Amelie, Johansson Åsa, Gyllensten Ulf, Soranzo Nicole, Mott Richard, Kranis Andreas, Marchini Jonathan

Abstract excerpt

Genetic association studies have yielded a wealth of biological discoveries. However, these studies have mostly analyzed one trait and one SNP at a time, thus failing to capture the underlying complexity of the data sets. Joint genotype-phenotype analyses of complex, high-dimensional data sets represent an important way to move beyond simple genome-wide association studies (GWAS) with great potential. The move to...

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PMID: 26901065
DOI: 10.1038/ng.3513
PMCID: PMC4817234

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