Article
A Persistent Tuberculosis Outbreak in the UK Is Characterized by Hydrophobic fadB4-Deficient Mycobacterium tuberculosis That Replicates Rapidly in Macrophages.
mBio - 20 Dec 2022
Farzand Robeena, Haigh Richard D, Monk Philip, Haldar Pranabashis, Patel Hemu, Pareek Manish, Verma Raman, Barer Michael R, Woltmann Gerrit, Ahyow Lauren, Jagatia Heena, Decker Jonathan, Mukamolova Galina V, Cooper Andrea M, Garton Natalie J, O'Hare Helen M
Abstract excerpt
The genetic diversity of Mycobacterium tuberculosis can influence disease severity and transmissibility. To better understand how this diversity influences individuals and communities, we phenotyped M. tuberculosis that was causing a persistent outbreak in the East Midlands, United Kingdom. Compared to nonoutbreak isolates, bacilli had higher lipid contents and more hydrophobic cell surfaces. In macrophage...
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