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Article

Mycobacterium tuberculosis complex Lineage 1: A neglected cause of tuberculosis.

PLoS neglected tropical diseases - 1 Oct 2025

Rojas Venus Marie R, Zwyer Michaela, Bouaouina Selim, Brites Daniela, Borrell Sonia, Gagneux Sebastien

Abstract excerpt

The Mycobacterium tuberculosis complex (MTBC) phylogenetic lineages 1-4 (L1-L4) are the main causes of human tuberculosis (TB). Until now, most of the focus in the TB field has been on MTBC L2 and L4, as these two lineages are geographically widespread and have been repeatedly associated with multidrug resistance. By comparison, MTBC L1 has received little attention, partially because of its restricted...

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Topics

Mycobacterium tuberculosis
Humans
Tuberculosis
Phylogeny
Genetic Variation
Animals
Virulence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Neglected Diseases

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Identifiers

PMID: 41066423
DOI: 10.1371/journal.pntd.0013513
PMCID: PMC12510564

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