Article
Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production.
Nature communications - 23 Apr 2020
Sousa Jeremy, Cá Baltazar, Maceiras Ana Raquel, Simões-Costa Luisa, Fonseca Kaori L, Fernandes Ana Isabel, Ramos Angélica, Carvalho Teresa, Barros Leandro, Magalhães Carlos, Chiner-Oms Álvaro, Machado Henrique, Veiga Maria Isabel, Singh Albel, Pereira Rui, Amorim António, Vieira Jorge, Vieira Cristina P, Bhatt Apoorva, Rodrigues Fernando, Rodrigues Pedro N S, Gagneux Sebastien, Castro António Gil, Guimarães João Tiago, Bastos Helder Novais, Osório Nuno S, Comas Iñaki, Saraiva Margarida
Abstract excerpt
Genetic diversity of Mycobacterium tuberculosis affects immune responses and clinical outcomes of tuberculosis (TB). However, how bacterial diversity orchestrates immune responses to direct distinct TB severities is unknown. Here we study 681 patients with pulmonary TB and show that M. tuberculosis isolates from cases with mild disease consistently induce robust cytokine responses in macrophages across multiple...
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