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Blood RNA transcripts show changes in inflammation and lipid metabolism in Alzheimer's disease and mitochondrial function in mild cognitive impairment

1 Jan 2024

Abstract excerpt

Background: Abnormal immunity in the periphery has been reported in the pathogenesis of Alzheimer's disease (AD). Objective: In this study, blood transcriptome analyses of patients with AD, those with mild cognitive impairment (MCI) due to AD, and heathy controls were performed to elucidate immune-related pathophysiology. Methods: The sample included 63 participants from a complete enumeration study of elderly...

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PMID: 40034360
DOI: 10.1177/25424823241307878

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