Article

Peripheral Monocyte-Derived Extracellular Vesicles Establish an Immune-Brain Communication Pathway in Alzheimer's Disease

2026-08-27

Abstract excerpt

Alzheimer's disease (AD) is increasingly recognized as a systemic disorder involving both central and peripheral immune dysfunction, yet the mechanisms by which peripheral immune cells influence neurodegeneration remain poorly understood. Here we identify a physiological extracellular vesicle (EV)-mediated route through which peripheral monocytes communicate with neurons and show that AD-associated monocyte remode...

Topics

Open a Topic to create a Post that cites this publication.

Uncategorized literature

Identifiers and source

Literature Corpus work: 422c0b06-9fd4-5514-958c-6f301c20673b
DOI: 10.64898/2026.08.27.747536

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Peripheral Monocyte-Derived Extracellular Vesicles Establish an Immune-Brain Communication Pathway in Alzheimer's DiseaseDOI 10.64898/2026.08.27.747536Read

Long Non-coding RNAs, Extracellular Vesicles and Inflammation in Alzheimer’s DiseaseSemantic proximity Read

Plasma extracellular vesicles from APOE3 Christchurch carriers display a protective phenotype in early stages of autosomal dominant Alzheimer's disease.Semantic proximity Read

Enrichment of neurodegenerative microglia signature in brain-derived extracellular vesicles isolated from Alzheimer’s disease mouse modelSemantic proximity Read

The role of monocytes and macrophages in the progression of Alzheimer’s diseaseSemantic proximity Read

Porcine plasma-derived extracellular vesicles orchestrate multi- target neuroimmune reconfiguration to alleviate Alzheimer's diseaseSemantic proximity Read

Circulating extracellular vesicles drive microglial senescence and neurodegeneration in Parkinson’s diseaseSemantic proximity Read

Assess Alzheimer’s Disease via Plasma Extracellular Vesicle-derived mRNASemantic proximity Read

BBB Dysfunction Defines the Aging Myeloid Landscape Favoring Immune Evasion for Glioma and Alzheimer's DiseaseSemantic proximity Read

Unique lipid cargoes in APOE4 human brain-derived extracellular vesicles recruit cell adhesion molecules and promote tauopathy in Alzheimer’s diseaseSemantic proximity Read

Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function.Semantic proximity Read

The role of macrophage plasticity in neurodegenerative diseasesSemantic proximity Read

High-Dimensional Single-Cell Analysis Reveals Coordinated Age-Dependent Neuroinflammatory Microglia-T cell Circuits in the BrainSemantic proximity Read