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Article

Alu Deletions in LAMA2 and CDH4 Genes Are Key Components of Polygenic Predictors of Longevity.

International journal of molecular sciences - 4 Nov 2022

Erdman Vera V, Karimov Denis D, Tuktarova Ilsia A, Timasheva Yanina R, Nasibullin Timur R, Korytina Gulnaz F

Abstract excerpt

Longevity is a unique human phenomenon and a highly stable trait, characterized by polygenicity. The longevity phenotype occurs due to the ability to successfully withstand the age-related genomic instability triggered by Alu elements. The purpose of our cross-sectional study was to evaluate the combined contribution of ACE*Ya5ACE, CDH4*Yb8NBC516, COL13A1*Ya5ac1986, HECW1*Ya5NBC182, LAMA2*Ya5-MLS19, PLAT*TPA25,...

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Identifiers

PMID: 36362280
DOI: 10.3390/ijms232113492
PMCID: PMC9657309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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