Article
Integrated genetic analyses revealed novel human longevity loci and reduced risks of multiple diseases in a cohort study of 15,651 Chinese individuals.
Aging cell - 1 Mar 2021
Liu Xiaomin, Song Zijun, Li Yan, Yao Yao, Fang Mingyan, Bai Chen, An Peng, Chen Huashuai, Chen Zhihua, Tang Biyao, Shen Juan, Gao Xiaotong, Zhang Mingrong, Chen Pengyu, Zhang Tao, Jia Huijue, Liu Xiao, Hou Yong, Yang Huanming, Wang Jian, Wang Fudi, Xu Xun, Min Junxia, Nie Chao, Zeng Yi
Abstract excerpt
There is growing interest in studying the genetic contributions to longevity, but limited relevant genes have been identified. In this study, we performed a genetic association study of longevity in a total of 15,651 Chinese individuals. Novel longevity loci, BMPER (rs17169634; p = 7.91 × 10-15 ) and TMEM43/XPC (rs1043943; p = 3.59 × 10-8 ), were identified in a case-control analysis of 11,045 individuals. BRAF...
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