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Article

Human longevity and 11p15.5: a study in 1321 centenarians.

European journal of human genetics : EJHG - 1 Nov 2009

Lescai Francesco, Blanché Helene, Nebel Almut, Beekman Marian, Sahbatou Mourad, Flachsbart Friederike, Slagboom Eline, Schreiber Stefan, Sorbi Sandro, Passarino Giuseppe, Franceschi Claudio

Abstract excerpt

The 11p15.5 chromosomal region (2.8 Mb) is of particular interest as it encloses five genes (HRAS1, SIRT3, TH, INS and IGF2), the variability of which was found to be associated with life extension by association studies. Mostly important, the above genes are homologous of genes that modulate lifespan in model organisms. We scanned the area in four European sample groups for a total of 1321 centenarians and 1140...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19367319
DOI: 10.1038/ejhg.2009.54
PMCID: PMC2986679

Genes

IGF2
INS
SIRT3
DEAF1
TSPAN32

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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