Article
Bayesian association scan reveals loci associated with human lifespan and linked biomarkers.
Nature communications - 27 Jul 2017
McDaid Aaron F, Joshi Peter K, Porcu Eleonora, Komljenovic Andrea, Li Hao, Sorrentino Vincenzo, Litovchenko Maria, Bevers Roel P J, Rüeger Sina, Reymond Alexandre, Bochud Murielle, Deplancke Bart, Williams Robert W, Robinson-Rechavi Marc, Paccaud Fred, Rousson Valentin, Auwerx Johan, Wilson James F, Kutalik Zoltán
Abstract excerpt
The enormous variation in human lifespan is in part due to a myriad of sequence variants, only a few of which have been revealed to date. Since many life-shortening events are related to diseases, we developed a Mendelian randomization-based method combining 58 disease-related GWA studies to derive longevity priors for all HapMap SNPs. A Bayesian association scan, informed by these priors, for parental age of...
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