Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A naturally occurring polymorphism at Drosophila melanogaster Lim3 Locus, a homolog of human LHX3/4, affects Lim3 transcription and fly lifespan.

PloS one - 7 Sept 2010

Rybina Olga Yu, Pasyukova Elena G

Abstract excerpt

Lim3 encodes an RNA polymerase II transcription factor with a key role in neuron specification. It was also identified as a candidate gene that affects lifespan. These pleiotropic effects indicate the fundamental significance of the potential interplay between neural development and lifespan cont...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila melanogaster
Share to Drosophila Proteins
Share to Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to LIM-Homeodomain Proteins

Share to Longevity

Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 20838645
DOI: 10.1371/journal.pone.0012621
PMCID: PMC2935391

Genes

LHX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20838645-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A naturally occurring polymorphism at Drosophila melanogaster Lim3 Locus, a homolog of human LHX3/4, affects Lim3 transcription and fly lifespan.PMID 20838645Read ↗

Alu Deletions in LAMA2 and CDH4 Genes Are Key Components of Polygenic Predictors of Longevity.Semantic proximity Read ↗

Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs.Semantic proximity Read ↗

Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration.Semantic proximity Read ↗

Su(var)3-9 mediates age-dependent increase in H3K9 methylation on TDP-43 promoter triggering neurodegenerationSemantic proximity Read ↗

Non-neutral evolution of H3.3-encoding genes occurs without alterations in protein sequenceSemantic proximity Read ↗

A genome-wide study replicates linkage of 3p22-24 to extreme longevity in humans and identifies possible additional loci.Semantic proximity Read ↗

Su(var)3-9 mediates age-dependent increase in H3K9 methylation on TDP-43 promoter triggering neurodegenerationSemantic proximity Read ↗

Drosophila americana as a model species for comparative studies on the molecular basis of phenotypic variation.Semantic proximity Read ↗

Molecular Cloning, Characterisation and Tissue-specific Expression of Human LAG3, a Member of the Novel Lag1 Protein FamilySemantic proximity Read ↗

Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome.Semantic proximity Read ↗

A Zebrafish Model for a Rare Genetic Disease Reveals a Conserved Role for FBXL3 in the Circadian Clock System.Semantic proximity Read ↗

Genetic variation in the Yolk protein expression network of Drosophila melanogaster: sex-biased negative correlations with longevity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.