Article
[Identification of single nucleotide polymorphisms in centenarians].
Revista espanola de geriatria y gerontologia - 1 Jan 2000
Gambini Juan, Gimeno-Mallench Lucía, Inglés Marta, Olaso Gloria, Abdelaziz Kheira Mohamed, Avellana Juan Antonio, Belenguer Ángel, Cruz Raquel, Mas-Bargues Cristina, Borras Consuelo, Viña José
Abstract excerpt
INTRODUCTION: Longevity is determined by genetic and external factors, such as nutritional, environmental, social, etc. Nevertheless, when living conditions are optimal, longevity is determined by genetic variations between individuals. In a same population, with relative genotypic homogeneity, subtle changes in the DNA sequence affecting a single nucleotide can be observed. These changes, called single...
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