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Article

The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age.

Mechanisms of ageing and development - 1 Jun 2024

Šetinc Maja, Celinšćak Željka, Bočkor Luka, Zajc Petranović Matea, Stojanović Marković Anita, Peričić Salihović Marijana, Deelen Joris, Škarić-Jurić Tatjana

Abstract excerpt

Genome-wide association studies and candidate gene studies have identified several genetic variants that might play a role in achieving longevity. This study investigates interactions between pairs of those single nucleotide polymorphisms (SNPs) and their effect on survival above the age of 85 in a sample of 327 Croatian individuals. Although none of the SNPs individually showed a significant effect on survival...

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Share to Aged, 80 and over
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Forkhead Box Protein O3

Share to PARK7 gene

Share to Genome-Wide Association Study

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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 38484896
DOI: 10.1016/j.mad.2024.111926
PMCID: PMC11166054

Genes

CDKN2B
FOXO3
PARK7
ERCC2
GHRHR
IL6
PTPN1
SH2B3
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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