Article
Fine-mapping CASP8 risk variants in breast cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2012
Camp Nicola J, Parry Marina, Knight Stacey, Abo Ryan, Elliott Graeme, Rigas Sushilaben H, Balasubramanian Sabapathy P, Reed Malcolm W R, McBurney Helen, Latif Ayse, Newman William G, Cannon-Albright Lisa A, Evans D Gareth, Cox Angela
Abstract excerpt
BACKGROUND: Multiple genome-wide and candidate gene association studies have been conducted in search of common risk variants for breast cancer. Recent large meta analyses, consolidating evidence from these studies, have been consistent in highlighting the caspase-8 (CASP8) gene as important in this regard. To define a risk haplotype and map the CASP8 gene region with respect to underlying susceptibility...
Topics
- Adult
- Aged
- Aged, 80 and over
- Breast Neoplasms
- Case-Control Studies
- Caspase 8
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study